g2 arrest — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
TQ0089	Juglanin		Apoptosis , JNK , Autophagy
	Juglanin is a JNK activator. Juglanin with inflammation and anti-tumor activities. It can induce apoptosis and autophagy on human breast cancer cells.		Apoptosis , JNK , Autophagy
T8873	Bractoppin		Others , DNA/RNA Synthesis
	Bractoppin is a drug-like inhibitor of phosphopeptide recognition by the human BRCA1 tandem (t)BRCT domain (IC50 = 0.074 μM), which selectively inhibits substrate binding with nanomolar potency in vitro. Structure-activi...		Others , DNA/RNA Synthesis
T2764	(S)-10-Hydroxycamptothecin	10-Hydroxycamptothecin,10-HCPT	Apoptosis , Topoisomerase
	(S)-10-Hydroxycamptothecin (10-HCPT) is a DNA topoisomerase I inhibitor, utilized as a clinical therapy agent against hepatoma.		Apoptosis , Topoisomerase
T3981	Acacetin	4'-Methoxyapigenin,5,7-Dihydroxy-4'-methoxyflavone,Linarigenin	Apoptosis , IAP , COX , Autophagy
	Acacetin (5,7-Dihydroxy-4'-methoxyflavone) is an O-methylated flavone found in various plants, shows antinociceptive, anti-inflammatory, and antioxidant activity in various research models.		Apoptosis , IAP , COX , Autophagy
T4189	4-Oxofenretinide	3-Keto fenretinide	cell cycle arrest
	4-Oxofenretinide (3-Keto fenretinide) , a recently identified fenretinide metabolite, induces marked G2-M cell cycle arrest and apoptosis.		cell cycle arrest
T3485	Probimane	AT-2153,MM-159	Others
	Probimane (AT-2153) had Anti-proliferative effects, cell cycle G2/M phase arrest and blocking of chromosome segregation in human tumor cell lines with MST-16.		Others
T78701	Tubulin inhibitor 32		Apoptosis
	Tubulin inhibitor 32 is an orally active novel microtubule inhibitor with antiproliferative and antitumor activity, inhibits microtubule polymerization, induces apoptosis and cell cycle arrest in G2/M phase.		Apoptosis
T9595	LP-261		Microtubule Associated
	LP-261 is a novel tubulin targeting anticancer agent that binds at the colchicine site on tubulin, inducing G2/M arrest.		Microtubule Associated
T5699	SSE15206		Apoptosis , Microtubule Associated
	SSE15206 is a microtubule polymerization inhibitor that overcomes multidrug resistance. Causes aberrant mitosis resulting in G2/M arrest due to incomplete spindle formation in cancer cells.		Apoptosis , Microtubule Associated
T77647	Tubulin polymerization-IN-43		Apoptosis , Microtubule Associated
	Tubulin polymerization-IN-43 is an inhibitor of tubulin polymerisation.Tubulin polymerization-IN-43 has multiple effects, disrupting the cellular microtubule network by targeting the colchicine locus and promoting cell c...		Apoptosis , Microtubule Associated
T64923	Sodium citrate	Citrosodine,Natrocitral	Others
	Sodium citrate (Natrocitral) is the sodium salt of citric acid.Citric acid trisodium induces apoptosis and cell cycle arrest at G2/M phase and S phase. Sodium citrate cause oxidative damage of the liver by means of the d...		Others
T60129	MT189	Antiproliferative agent-14	Microtubule Associated
	MT189 (Antiproliferative agent-14) is a potent tubulin polymerization inhibitor, with an IC50 of 3.41 μM. Antiproliferative agent-14 has excellent antiproliferative activity. Antiproliferative agent-14 possess the abilit...		Microtubule Associated
T67746	IMS2186		Others
	IMS2186 is a reagent with activity of antichoroidal neovascularization (CNV). IMS2186 could arrest cancer cell cycle in G2/M phase, result in exerting anti-proliferation and anti-angiogenesis effects. IMS2186 reduces the...		Others
T23601	ABC1183	ABC 1183,ABC-1183	GSK-3 , CDK
	ABC1183 is a novel diaminothiazole that inhibits GSK3α, GSK3β and CDK9. ABC1183 inhibits the growth of a numerous cancer cell lines by decreasing cell survival by inducing G2/M arrest and through altering GSK3, glycogen ...		GSK-3 , CDK
T16750	Rigosertib	ON-01910	Apoptosis , FLT , PLK , PI3K , Bcr-Abl , CDK , PDGFR , Src
	Rigosertib (ON-01910) is a selective and non-ATP-competitive inhibitor of PLK1 (IC50: 9 nM). Rigosertib is a multi-kinase inhibitor and a selective anti-cancer agent, which induces apoptosis by inhibition of the PI3 kina...		Apoptosis , FLT , PLK , PI3K , Bcr-Abl , CDK , PDGFR , Src
T28886	Suprafenacine	N'-[(E)-(4-methylphenyl)methylidene]-4,5,6,7-tetrahydro-1H-indazole-3-carbohydrazide	Microtubule Associated
	Suprafenacine (N'-[(E)-(4-methylphenyl)methylidene]-4,5,6,7-tetrahydro-1H-indazole-3-carbohydrazide) is a cell-permeable microtubule destabilizer that induces cell cycle arrest and apoptosis in G2/M phase. Suprafenacine ...		Microtubule Associated
T3124	Carbendazim	Bavistin,Carbendazole,Mercarzole	Antifungal
	Carbendazim (Mercarzole) is a broad-spectrum benzimidazole antifungal with potential antimitotic and antineoplastic activities. Although the exact mechanism of action is unclear, carbendazim appears to binds to an unspec...		Antifungal
T8756	KRAS inhibitor-9	DUN09716	Apoptosis , Ras
	KRAS inhibitor-9 (DUN09716) is a potent KRAS inhibitor with Kd of 92 μM that blocks the formation of GTP-KRAS and downstream activation of KRAS. KRAS inhibitor-9 causes G2/M cell cycle arrest and induces apoptosis. KRAS ...		Apoptosis , Ras
T27407	GDC0575 monohydrochloride	ARRY-575,GDC-0575,GDC 0575,ARRY575,GDC0575	Chk
	GDC0575 monohydrochloride (ARRY575) is a potent and selective inhibitor of cell cycle checkpoint kinase 1 (Chk1) with an IC50 of 1.2 nM. GDC-0575 specifically binds to and inhibits Chk1; this may result in tumor cells by...		Chk
T2220	2-Methoxyestradiol	NSC-659853,2-MeOE2,2-ME2	Apoptosis , Reactive Oxygen Species , Microtubule Associated , Endogenous Metabolite , HIF , Autophagy
	2-Methoxyestradiol (2-ME2) is an orally bioavailable estradiol metabolite with potential antineoplastic activity. 2-Methoxyestradiol inhibits angiogenesis by reducing endothelial cell proliferation and inducing endotheli...